Compound Detail
CHEMBL300072
PRANAZEPIDE 🧪 Phase II
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🧪 Phase II
O=C(N[C@H]1N=C(c2ccccc2F)c2cccc3c2N(CC3)C1=O)c1cc2ccccc2[nH]1
Basic Information
| ChEMBL ID | CHEMBL300072 |
| Name | PRANAZEPIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WKJDXKWFGJWGAS-XMMPIXPASA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names
Molecular Properties
438.5
MW (Da)
3.80
ALogP
3
HBA
2
HBD
77.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 9.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholecystokinin receptor type A CHEMBL2871 | IC50 | 9.17 | 9.17 | 0.7 | 1 |
| Gastrin/cholecystokinin type B receptor CHEMBL298 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholecystokinin receptor type A | IC50 | = | 0.67 | nM | 9.17 | Inhibition of [125I]Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin ty... | - |
| Gastrin/cholecystokinin type B receptor | IC50 | = | 310.0 | nM | 6.51 | Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00609-9 | Gastrin/cholecystokinin type B receptor | 1 |
| - | 10.1016/S0960-894X(96)00609-9 | Cholecystokinin receptor type A | 1 |
| - | 10.1016/S0960-894X(96)00609-9 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine