Assay Detail
Binding
CHEMBL662416
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Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type A receptor of rat pancreatic membranes
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dual CCK-A and -B receptor antagonists (I) C9-methyl-1,4-benzodiazepines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.92 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285921 | — | — | 2 | 8.04 |
| CHEMBL9387 | L-365260 | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285921 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL9387 | L-365260 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL285921 | — | IC50 | = | 670.0 | nM | 6.17 |