Assay Detail
Binding
CHEMBL662420
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Displacement of [125I]-BH CCK-8S from Cholecystokinin type A receptor in rat pancreas
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.63 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9387 | L-365260 | — | 1 | 6.13 |
| CHEMBL103119 | — | — | 1 | 5.81 |
| CHEMBL420783 | L-740093 | — | 1 | 5.79 |
| CHEMBL319180 | — | — | 1 | 5.72 |
| CHEMBL101528 | — | — | 1 | 5.50 |
| CHEMBL105273 | — | — | 1 | 5.42 |
| CHEMBL103229 | — | — | 1 | 5.37 |
| CHEMBL100502 | — | — | 1 | 5.28 |
| CHEMBL102633 | — | — | 1 | - |
| CHEMBL102537 | — | — | 1 | - |
| CHEMBL431832 | — | — | 1 | - |
| CHEMBL103791 | — | — | 1 | - |
| CHEMBL318360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9387 | L-365260 | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL103119 | — | IC50 | = | 1559.0 | nM | 5.81 |
| CHEMBL420783 | L-740093 | IC50 | = | 1604.0 | nM | 5.79 |
| CHEMBL319180 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL101528 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL105273 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL103229 | — | IC50 | = | 4257.0 | nM | 5.37 |
| CHEMBL100502 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL102633 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL102537 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL431832 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL103791 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL318360 | — | IC50 | > | 3000.0 | nM | - |