Assay Detail
Binding
CHEMBL662425
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Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type A receptor in pancreatic tissue
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.91 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110202 | — | — | 1 | 6.82 |
| CHEMBL168263 | — | — | 1 | 6.70 |
| CHEMBL2093059 | — | — | 1 | 6.40 |
| CHEMBL9387 | L-365260 | — | 1 | 6.13 |
| CHEMBL2110201 | — | — | 1 | 6.10 |
| CHEMBL168253 | — | — | 1 | 5.80 |
| CHEMBL170275 | — | — | 1 | 5.52 |
| CHEMBL169362 | — | — | 1 | 5.52 |
| CHEMBL168903 | — | — | 1 | 5.52 |
| CHEMBL353509 | — | — | 1 | 5.52 |
| CHEMBL22003 | — | — | 1 | 5.52 |
| CHEMBL166941 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110202 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL168263 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2093059 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL9387 | L-365260 | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL2110201 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL168253 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL170275 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL169362 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL168903 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL353509 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL22003 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL166941 | — | IC50 | = | 4080.0 | nM | 5.39 |