Assay Detail
Binding
CHEMBL663192
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Displacement of [3H]LTD4 on guinea pig lung parenchymal membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung parenchyma |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.06 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50370 | — | — | 1 | 9.52 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.52 |
| CHEMBL52492 | — | — | 1 | 9.30 |
| CHEMBL51891 | — | — | 1 | 9.30 |
| CHEMBL301498 | — | — | 1 | 9.10 |
| CHEMBL300846 | — | — | 1 | 9.00 |
| CHEMBL431348 | — | — | 1 | 8.85 |
| CHEMBL49519 | — | — | 1 | 7.30 |
| CHEMBL49298 | — | — | 1 | 7.10 |
| CHEMBL295268 | — | — | 1 | 6.80 |
| CHEMBL300940 | — | — | 1 | 6.80 |
| CHEMBL51544 | — | — | 1 | 6.70 |
| CHEMBL162358 | TOMELUKAST | 2.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50370 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL603 | ZAFIRLUKAST | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL52492 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL51891 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL301498 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL300846 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL431348 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL49519 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL49298 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL295268 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL300940 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL51544 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL162358 | TOMELUKAST | Ki | = | 2818.0 | nM | 5.55 |