Assay Detail
Binding
CHEMBL663193
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Binding affinity against LTD4 receptor in guinea pig lung membranes.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.36 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47430 | — | — | 1 | 10.00 |
| CHEMBL46663 | — | — | 1 | 9.92 |
| CHEMBL44734 | — | — | 1 | 9.52 |
| CHEMBL22033 | ICI-198615 | — | 1 | 9.52 |
| CHEMBL47662 | — | — | 1 | 8.96 |
| CHEMBL296097 | — | — | 1 | 8.92 |
| CHEMBL46343 | — | — | 1 | 8.89 |
| CHEMBL49449 | — | — | 1 | 8.68 |
| CHEMBL47376 | — | — | 1 | 8.60 |
| CHEMBL18518 | RG-12525 | — | 1 | 8.52 |
| CHEMBL295368 | — | — | 1 | 8.20 |
| CHEMBL45965 | — | — | 1 | 7.89 |
| CHEMBL49696 | — | — | 1 | 7.82 |
| CHEMBL295664 | — | — | 1 | 7.75 |
| CHEMBL45850 | — | — | 1 | 7.52 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.29 |
| CHEMBL46362 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47430 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL46663 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL44734 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL22033 | ICI-198615 | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL47662 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL296097 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL46343 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL49449 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL47376 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL18518 | RG-12525 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL295368 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL45965 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL49696 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL295664 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL45850 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL267475 | FPL-55712 | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL46362 | — | Ki | = | 7000.0 | nM | 5.16 |