Assay Detail
Binding
CHEMBL663216
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In vitro binding of Cysteinyl leukotriene receptor 1 to guinea pig lung membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.24 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96224 | — | — | 1 | 9.40 |
| CHEMBL96206 | — | — | 1 | 9.22 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96224 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL96206 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL21333 | PRANLUKAST | Ki | = | 0.8 | nM | 9.10 |