Assay Detail
Binding
CHEMBL663405
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Inhibition of human Coagulation factor X was determined
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Analyses of activity for factor Xa inhibitors based on Monte Carlo simulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 60 | 6.47 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419651 | — | — | 1 | 8.74 |
| CHEMBL84065 | — | — | 1 | 8.62 |
| CHEMBL82925 | — | — | 1 | 8.52 |
| CHEMBL82006 | — | — | 1 | 8.22 |
| CHEMBL309879 | — | — | 1 | 8.10 |
| CHEMBL79529 | — | — | 1 | 8.08 |
| CHEMBL309541 | — | — | 1 | 8.05 |
| CHEMBL79828 | — | — | 1 | 7.89 |
| CHEMBL79986 | — | — | 1 | 7.85 |
| CHEMBL82456 | — | — | 1 | 7.64 |
| CHEMBL310373 | — | — | 1 | 7.58 |
| CHEMBL48604 | — | — | 1 | 7.23 |
| CHEMBL84275 | — | — | 1 | 7.19 |
| CHEMBL70730 | — | — | 1 | 7.10 |
| CHEMBL315014 | — | — | 1 | 7.07 |
| CHEMBL314047 | — | — | 1 | 6.85 |
| CHEMBL79258 | — | — | 1 | 6.80 |
| CHEMBL83175 | — | — | 1 | 6.80 |
| CHEMBL83675 | — | — | 1 | 6.80 |
| CHEMBL309717 | — | — | 1 | 6.75 |
| CHEMBL81893 | — | — | 1 | 6.66 |
| CHEMBL81579 | — | — | 1 | 6.55 |
| CHEMBL81932 | — | — | 1 | 6.55 |
| CHEMBL84419 | — | — | 1 | 6.50 |
| CHEMBL314591 | — | — | 1 | 6.40 |
| CHEMBL82175 | — | — | 1 | 6.34 |
| CHEMBL84502 | — | — | 1 | 6.30 |
| CHEMBL83054 | — | — | 1 | 6.28 |
| CHEMBL419661 | — | — | 1 | 6.21 |
| CHEMBL350455 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419651 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL84065 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL82925 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL82006 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL309879 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL79529 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL309541 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL79828 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL79986 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL82456 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL310373 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL48604 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL84275 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL70730 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL315014 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL314047 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL79258 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL83175 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL83675 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL309717 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL81893 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL81579 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL81932 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL84419 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL314591 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL82175 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL84502 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL83054 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL419661 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL350455 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL79501 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL311608 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL83798 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL80119 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL157374 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL79735 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL80017 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL84379 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL83367 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL310575 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL315796 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL79996 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL83106 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL157316 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL83003 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL84030 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL84410 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL83903 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL152611 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL83978 | — | Ki | = | 2400.0 | nM | 5.62 |