Assay Detail
ADMET
CHEMBL663578
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Inhibition of recombinant human Cytochrome P450 3A4
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.55 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101168 | — | — | 1 | 6.35 |
| CHEMBL321051 | — | — | 1 | 4.30 |
| CHEMBL100917 | — | — | 1 | 4.29 |
| CHEMBL103313 | — | — | 1 | 4.19 |
| CHEMBL267865 | — | — | 1 | 4.15 |
| CHEMBL319862 | — | — | 1 | 4.03 |
| CHEMBL101180 | — | — | 1 | - |
| CHEMBL103651 | — | — | 1 | - |
| CHEMBL103320 | — | — | 1 | - |
| CHEMBL100899 | — | — | 1 | - |
| CHEMBL103163 | — | — | 1 | - |
| CHEMBL101296 | — | — | 1 | - |
| CHEMBL445120 | — | — | 1 | - |
| CHEMBL317798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101168 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL321051 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL100917 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL103313 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL267865 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL319862 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL101180 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103651 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103320 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL100899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL101296 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL445120 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL317798 | — | IC50 | > | 100000.0 | nM | - |