Assay Detail
ADMET
CHEMBL663952
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Inhibition of cytochrome P450 3A4
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.69 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115876 | — | — | 1 | 6.60 |
| CHEMBL113227 | — | — | 1 | 6.46 |
| CHEMBL112532 | — | — | 1 | 6.46 |
| CHEMBL262968 | — | — | 1 | 6.38 |
| CHEMBL112592 | — | — | 1 | 6.20 |
| CHEMBL113275 | — | — | 1 | 5.35 |
| CHEMBL113018 | — | — | 1 | 5.25 |
| CHEMBL114297 | — | — | 1 | 4.41 |
| CHEMBL320105 | — | — | 1 | 4.11 |
| CHEMBL114555 | — | — | 1 | - |
| CHEMBL325429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115876 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL113227 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL112532 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL262968 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL112592 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL113275 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL113018 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL114297 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL320105 | — | IC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL114555 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325429 | — | IC50 | > | 100000.0 | nM | - |