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Assay Detail

CHEMBL664161

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against ovine COX-1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 1 (CHEMBL2949)
Type SINGLE PROTEIN
Organism Ovis aries

Publication

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.
Pinto DJ, Batt DG, Pitts WJ, Petraitis JJ, Orwat MJ, Wang S, Jetter JW, Sherk SR, Houghton GC, Copeland RA, Covington MB, Trzaskos JM, Magolda RL.
Bioorg Med Chem Lett (1999) 9 : 919 -924
PubMed 10230611 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.53 4.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367328 1 4.77
CHEMBL172128 1 4.46
CHEMBL171147 1 4.37
CHEMBL355677 1 -
CHEMBL171471 1 -
CHEMBL173186 1 -
CHEMBL426767 1 -
CHEMBL174314 1 -
CHEMBL173169 1 -
CHEMBL170780 1 -
CHEMBL353688 1 -
CHEMBL172194 1 -
CHEMBL96842 1 -
CHEMBL170522 1 -
CHEMBL171416 1 -
CHEMBL172364 1 -
CHEMBL173283 1 -
CHEMBL101503 1 -
CHEMBL170180 1 -
CHEMBL171417 1 -
CHEMBL172720 1 -
CHEMBL171299 1 -
CHEMBL170834 1 -
CHEMBL369699 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367328 IC50 = 17000.0 nM 4.77
CHEMBL172128 IC50 = 35000.0 nM 4.46
CHEMBL171147 IC50 = 43000.0 nM 4.37
CHEMBL355677 IC50 > 300000.0 nM -
CHEMBL171471 IC50 > 1000000.0 nM -
CHEMBL173186 IC50 > 300000.0 nM -
CHEMBL426767 IC50 = 232000.0 nM -
CHEMBL174314 IC50 > 300000.0 nM -
CHEMBL173169 IC50 = 404000.0 nM -
CHEMBL170780 IC50 > 1000000.0 nM -
CHEMBL353688 IC50 > 300000.0 nM -
CHEMBL172194 IC50 > 300000.0 nM -
CHEMBL96842 IC50 > 1000000.0 nM -
CHEMBL170522 IC50 > 300000.0 nM -
CHEMBL171416 IC50 > 1000000.0 nM -
CHEMBL172364 IC50 > 1000000.0 nM -
CHEMBL173283 IC50 > 1000000.0 nM -
CHEMBL101503 IC50 > 1000000.0 nM -
CHEMBL170180 IC50 > 100000.0 nM -
CHEMBL171417 IC50 > 300000.0 nM -
CHEMBL172720 IC50 > 300000.0 nM -
CHEMBL171299 IC50 > 300000.0 nM -
CHEMBL170834 IC50 > 300000.0 nM -
CHEMBL369699 IC50 > 300000.0 nM -