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Assay Detail

CHEMBL664162

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Tissue Seminal vesicle
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 1 (CHEMBL2949)
Type SINGLE PROTEIN
Organism Ovis aries

Publication

N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Connolly PJ, Wetter SK, Beers KN, Hamel SC, Chen RH, Wachter MP, Ansell J, Singer MM, Steber M, Ritchie DM, Argentieri DC.
Bioorg Med Chem Lett (1999) 9 : 979 -984
PubMed 10230624 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.80 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL175153 1 6.51
CHEMBL368682 1 6.41
CHEMBL264200 1 6.38
CHEMBL177727 1 6.37
CHEMBL174684 1 6.28
CHEMBL176844 1 6.23
CHEMBL368546 1 5.99
CHEMBL174616 1 5.89
CHEMBL174501 1 5.79
CHEMBL367010 1 5.60
CHEMBL435907 1 5.59
CHEMBL176200 1 5.53
CHEMBL316040 TEPOXALIN 2.0 1 5.34
CHEMBL175372 1 5.22
CHEMBL176945 1 5.21
CHEMBL369848 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL175153 IC50 = 310.0 nM 6.51
CHEMBL368682 IC50 = 390.0 nM 6.41
CHEMBL264200 IC50 = 420.0 nM 6.38
CHEMBL177727 IC50 = 430.0 nM 6.37
CHEMBL174684 IC50 = 530.0 nM 6.28
CHEMBL176844 IC50 = 590.0 nM 6.23
CHEMBL368546 IC50 = 1020.0 nM 5.99
CHEMBL174616 IC50 = 1300.0 nM 5.89
CHEMBL174501 IC50 = 1620.0 nM 5.79
CHEMBL367010 IC50 = 2510.0 nM 5.60
CHEMBL435907 IC50 = 2540.0 nM 5.59
CHEMBL176200 IC50 = 2930.0 nM 5.53
CHEMBL316040 TEPOXALIN IC50 = 4600.0 nM 5.34
CHEMBL175372 IC50 = 6000.0 nM 5.22
CHEMBL176945 IC50 = 6100.0 nM 5.21
CHEMBL369848 IC50 = 32000.0 nM 4.50