Assay Detail
ADMET
CHEMBL664805
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Inhibitory activity against cytochrome P450 3A4
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.16 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283255 | — | — | 1 | 6.70 |
| CHEMBL287400 | — | — | 1 | 6.68 |
| CHEMBL26678 | — | — | 1 | 6.58 |
| CHEMBL25903 | — | — | 1 | 5.91 |
| CHEMBL283438 | — | — | 1 | 5.87 |
| CHEMBL281284 | — | — | 1 | 5.82 |
| CHEMBL281743 | — | — | 1 | 5.75 |
| CHEMBL27257 | — | — | 1 | 5.60 |
| CHEMBL29743 | — | — | 1 | 5.24 |
| CHEMBL282156 | — | — | 1 | 5.18 |
| CHEMBL29631 | — | — | 1 | 5.09 |
| CHEMBL27415 | — | — | 1 | 5.03 |
| CHEMBL26369 | — | — | 1 | 5.03 |
| CHEMBL285343 | — | — | 1 | 4.93 |
| CHEMBL25867 | — | — | 1 | 4.90 |
| CHEMBL26039 | — | — | 1 | 4.82 |
| CHEMBL430724 | — | — | 1 | 4.75 |
| CHEMBL281326 | — | — | 1 | 4.73 |
| CHEMBL282365 | — | — | 1 | 4.71 |
| CHEMBL418382 | — | — | 1 | 4.70 |
| CHEMBL28629 | — | — | 1 | 4.68 |
| CHEMBL26150 | — | — | 1 | 4.58 |
| CHEMBL439727 | — | — | 1 | 4.50 |
| CHEMBL281496 | — | — | 1 | 4.47 |
| CHEMBL25905 | — | — | 1 | 4.43 |
| CHEMBL284024 | — | — | 1 | 4.37 |
| CHEMBL25731 | — | — | 1 | 4.27 |
| CHEMBL27007 | — | — | 1 | - |
| CHEMBL28168 | — | — | 1 | - |
| CHEMBL284676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283255 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL287400 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL26678 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL25903 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL283438 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL281284 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL281743 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL27257 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL29743 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL282156 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL29631 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL27415 | — | IC50 | = | 9440.0 | nM | 5.03 |
| CHEMBL26369 | — | IC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL285343 | — | IC50 | = | 11790.0 | nM | 4.93 |
| CHEMBL25867 | — | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL26039 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL430724 | — | IC50 | = | 17850.0 | nM | 4.75 |
| CHEMBL281326 | — | IC50 | = | 18480.0 | nM | 4.73 |
| CHEMBL282365 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL418382 | — | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL28629 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL26150 | — | IC50 | = | 26410.0 | nM | 4.58 |
| CHEMBL439727 | — | IC50 | = | 31310.0 | nM | 4.50 |
| CHEMBL281496 | — | IC50 | = | 33690.0 | nM | 4.47 |
| CHEMBL25905 | — | IC50 | = | 36820.0 | nM | 4.43 |
| CHEMBL284024 | — | IC50 | = | 42260.0 | nM | 4.37 |
| CHEMBL25731 | — | IC50 | = | 53810.0 | nM | 4.27 |
| CHEMBL27007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL28168 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL284676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL30052 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283253 | — | IC50 | > | 100000.0 | nM | - |