Assay Detail
Binding
CHEMBL664922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL87383 | — | — | 1 | 7.16 |
| CHEMBL313034 | — | — | 1 | 7.10 |
| CHEMBL313553 | — | — | 1 | 6.70 |
| CHEMBL87013 | — | — | 1 | 6.66 |
| CHEMBL49246 | — | — | 1 | 6.51 |
| CHEMBL314001 | — | — | 1 | 6.42 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.41 |
| CHEMBL313440 | — | — | 1 | 6.36 |
| CHEMBL85188 | — | — | 1 | 6.20 |
| CHEMBL87730 | — | — | 1 | 6.19 |
| CHEMBL85576 | — | — | 1 | 6.18 |
| CHEMBL55764 | — | — | 1 | 6.16 |
| CHEMBL314387 | — | — | 1 | 6.16 |
| CHEMBL444587 | — | — | 1 | 6.10 |
| CHEMBL88004 | — | — | 1 | 6.08 |
| CHEMBL313131 | — | — | 1 | 6.08 |
| CHEMBL85958 | — | — | 1 | 6.07 |
| CHEMBL313680 | — | — | 1 | 5.98 |
| CHEMBL85573 | — | — | 1 | 5.94 |
| CHEMBL85875 | — | — | 1 | 5.90 |
| CHEMBL2115210 | — | — | 1 | 5.83 |
| CHEMBL82853 | — | — | 1 | 5.75 |
| CHEMBL86085 | — | — | 1 | 5.70 |
| CHEMBL87423 | — | — | 1 | 5.59 |
| CHEMBL2114205 | — | — | 1 | 5.57 |
| CHEMBL87549 | — | — | 1 | 5.36 |
| CHEMBL315297 | — | — | 1 | 5.27 |
| CHEMBL85919 | — | — | 1 | 5.21 |
| CHEMBL441062 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL87383 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL313034 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL313553 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL87013 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL49246 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL314001 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL313440 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL85188 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL87730 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL85576 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL55764 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL314387 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL444587 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL88004 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL313131 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL85958 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL313680 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL85573 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL85875 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2115210 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL82853 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL86085 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL87423 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL2114205 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL87549 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL315297 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL85919 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL441062 | — | IC50 | = | 7800.0 | nM | 5.11 |