Assay Detail
Functional
CHEMBL665014
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In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.44 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.25 |
| CHEMBL418866 | — | — | 1 | 8.24 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.28 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL418866 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 1020.0 | nM | 5.99 |