Assay Detail
Binding
CHEMBL665364
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Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium avium
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.23 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87730 | — | — | 1 | 5.69 |
| CHEMBL88004 | — | — | 1 | 5.43 |
| CHEMBL86085 | — | — | 1 | 5.41 |
| CHEMBL85875 | — | — | 1 | 5.39 |
| CHEMBL314001 | — | — | 1 | 5.36 |
| CHEMBL85188 | — | — | 1 | 5.35 |
| CHEMBL82853 | — | — | 1 | 5.27 |
| CHEMBL85958 | — | — | 1 | 5.27 |
| CHEMBL87549 | — | — | 1 | 5.13 |
| CHEMBL313131 | — | — | 1 | 4.61 |
| CHEMBL315297 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87730 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL88004 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL86085 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL85875 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL314001 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL85188 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL82853 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL85958 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL87549 | — | IC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL313131 | — | IC50 | = | 24540.0 | nM | 4.61 |
| CHEMBL315297 | — | IC50 | = | 25200.0 | nM | 4.60 |