Assay Detail
Functional
CHEMBL665629
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In vitro inhibitory concentration of compound against proliferation of DU145 prostate carcinoma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.43 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35388 | — | — | 1 | 4.70 |
| CHEMBL34749 | — | — | 1 | 4.40 |
| CHEMBL32894 | — | — | 1 | 4.30 |
| CHEMBL35165 | — | — | 1 | 4.30 |
| CHEMBL34896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35388 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL34749 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL32894 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL35165 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL34896 | — | IC50 | > | 50000.0 | nM | - |