Assay Detail
Binding
CHEMBL665995
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Binding affinity to human CBG receptor (corticosteroid-binding globulins)
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Comparative molecular active site analysis (CoMASA). 1. An approach to rapid evaluation of 3D QSAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.38 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 7.88 |
| CHEMBL110739 | CORTICOSTERONE | 3.0 | 2 | 7.88 |
| CHEMBL253144 | CORTODOXONE | 2.0 | 1 | 7.88 |
| CHEMBL1062 | HYDROXYPROGESTERONE | — | 1 | 7.74 |
| CHEMBL432825 | — | — | 1 | 7.69 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | — | 1 | 7.65 |
| CHEMBL1091 | HYDROCORTISONE ACETATE | 4.0 | 1 | 7.55 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.51 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.38 |
| CHEMBL433198 | — | — | 1 | 7.12 |
| CHEMBL1499 | CORTISONE | 3.0 | 1 | 6.89 |
| CHEMBL284109 | — | — | 1 | 6.82 |
| CHEMBL284253 | — | — | 1 | 6.78 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 6.72 |
| CHEMBL273453 | ALDOSTERONE | 2.0 | 1 | 6.28 |
| CHEMBL2311120 | — | — | 1 | 6.25 |
| CHEMBL757 | NANDROLONE | 3.0 | 1 | 6.14 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 5.92 |
| CHEMBL93948 | — | — | 1 | 5.80 |
| CHEMBL274826 | ANDROSTENEDIONE | -1.0 | 1 | 5.76 |
| CHEMBL87285 | ANDROSTERONE | — | 1 | 5.61 |
| CHEMBL253363 | PREGNENOLONE | 1.0 | 1 | 5.23 |
| CHEMBL85799 | ETIOCHOLANOLONE | — | 1 | 5.23 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | 5.00 |
| CHEMBL316048 | ANDROSTANEDIOL | — | 1 | 5.00 |
| CHEMBL440283 | ANDROSTENEDIOL | -1.0 | 1 | 5.00 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 5.00 |
| CHEMBL92890 | HYDROXYPREGNENOLONE | — | 1 | 5.00 |
| CHEMBL193482 | ESTRIOL | 4.0 | 1 | 5.00 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253144 | CORTODOXONE | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL389621 | HYDROCORTISONE | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL110739 | CORTICOSTERONE | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL1062 | HYDROXYPROGESTERONE | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL432825 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL1091 | HYDROCORTISONE ACETATE | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL131 | PREDNISOLONE | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL103 | PROGESTERONE | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL110739 | CORTICOSTERONE | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL433198 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL1499 | CORTISONE | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL284109 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL284253 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL386630 | TESTOSTERONE | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL273453 | ALDOSTERONE | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL2311120 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL757 | NANDROLONE | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL27769 | STANOLONE | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL93948 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL274826 | ANDROSTENEDIONE | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL87285 | ANDROSTERONE | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL253363 | PREGNENOLONE | Ki | = | 5888.44 | nM | 5.23 |
| CHEMBL85799 | ETIOCHOLANOLONE | Ki | = | 5888.44 | nM | 5.23 |
| CHEMBL90593 | PRASTERONE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL316048 | ANDROSTANEDIOL | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL92890 | HYDROXYPREGNENOLONE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL135 | ESTRADIOL | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL193482 | ESTRIOL | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1405 | ESTRONE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL440283 | ANDROSTENEDIOL | Ki | = | 10000.0 | nM | 5.00 |