Assay Detail
ADMET
CHEMBL666009
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Concentration required to inhibit cytochrome P450 3A4.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.86 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358880 | — | — | 1 | 6.94 |
| CHEMBL112532 | — | — | 1 | 6.46 |
| CHEMBL151170 | — | — | 1 | 6.05 |
| CHEMBL359116 | — | — | 1 | 5.12 |
| CHEMBL151207 | — | — | 1 | 5.04 |
| CHEMBL151354 | — | — | 1 | 4.64 |
| CHEMBL434317 | — | — | 1 | 4.57 |
| CHEMBL151646 | — | — | 1 | 4.53 |
| CHEMBL150999 | — | — | 1 | 4.35 |
| CHEMBL151280 | — | — | 1 | 4.29 |
| CHEMBL358214 | — | — | 1 | 4.29 |
| CHEMBL358216 | — | — | 1 | 4.24 |
| CHEMBL267865 | — | — | 1 | 4.18 |
| CHEMBL149750 | — | — | 1 | 4.15 |
| CHEMBL151037 | — | — | 1 | 4.03 |
| CHEMBL422858 | — | — | 1 | - |
| CHEMBL347303 | — | — | 1 | - |
| CHEMBL151038 | — | — | 1 | - |
| CHEMBL150681 | — | — | 1 | - |
| CHEMBL150653 | — | — | 1 | - |
| CHEMBL356594 | — | — | 1 | - |
| CHEMBL151449 | — | — | 1 | - |
| CHEMBL151974 | — | — | 1 | - |
| CHEMBL150278 | — | — | 1 | - |
| CHEMBL433737 | — | — | 1 | - |
| CHEMBL345544 | — | — | 1 | - |
| CHEMBL150146 | — | — | 1 | - |
| CHEMBL348263 | — | — | 1 | - |
| CHEMBL150799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358880 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL112532 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL151170 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL359116 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL151207 | — | IC50 | = | 9170.0 | nM | 5.04 |
| CHEMBL151354 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL434317 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL151646 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL150999 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL151280 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL358214 | — | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL358216 | — | IC50 | = | 58100.0 | nM | 4.24 |
| CHEMBL267865 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL149750 | — | IC50 | = | 70600.0 | nM | 4.15 |
| CHEMBL151037 | — | IC50 | = | 93800.0 | nM | 4.03 |
| CHEMBL422858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150653 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL356594 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151449 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151974 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150799 | — | IC50 | > | 100000.0 | nM | - |