Assay Detail
ADMET
CHEMBL666065
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Inhibition of dog Cytochrome P450 3A by macrocycles
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.31 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80702 | — | — | 1 | 6.22 |
| CHEMBL53821 | — | — | 1 | 5.30 |
| CHEMBL78742 | — | — | 1 | 5.21 |
| CHEMBL526466 | — | — | 1 | 4.98 |
| CHEMBL526656 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80702 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL53821 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL78742 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL526466 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL526656 | — | IC50 | = | 14800.0 | nM | 4.83 |