Assay Detail
Binding
CHEMBL666358
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Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.30 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431946 | — | — | 1 | 7.13 |
| CHEMBL276326 | — | — | 1 | 6.97 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.63 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.47 |
| CHEMBL19130 | — | — | 1 | 6.10 |
| CHEMBL54183 | — | — | 1 | 6.07 |
| CHEMBL288096 | — | — | 1 | 6.04 |
| CHEMBL53294 | — | — | 1 | 5.75 |
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 5.53 |
| CHEMBL53445 | — | — | 1 | - |
| CHEMBL301761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431946 | — | Ki | = | 74.5 | nM | 7.13 |
| CHEMBL276326 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL53 | APOMORPHINE | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL19130 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL54183 | — | Ki | = | 851.0 | nM | 6.07 |
| CHEMBL288096 | — | Ki | = | 915.0 | nM | 6.04 |
| CHEMBL53294 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL416288 | (S)APOMORPHINE | Ki | = | 2980.0 | nM | 5.53 |
| CHEMBL53445 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL301761 | — | Ki | < | 10000.0 | nM | - |