Compound Detail
CHEMBL301761
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL301761 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QGJWYJSOGNAUCY-AWEZNQCLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
2.86
ALogP
4
HBA
2
HBD
52.9
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 7.46 | 7.46 | 34.7 | 1 |
| Dopamine receptor CHEMBL2096970 | Ki | 6.79 | 6.79 | 162.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 34.7 | nM | 7.46 | Binding affinity at rat striatal Dopamine receptor D2 using [3H]- piperone radio... | 1971309 |
| Dopamine receptor | Ki | = | 162.0 | nM | 6.79 | Agonistic activity against calf striatal Dopamine receptor using [3H]- ADTN radi... | 1971309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1971309 | 10.1021/jm00168a040 | Dopamine receptor | 1 |
| 1971309 | 10.1021/jm00168a040 | D(1A) dopamine receptor | 1 |
| 1971309 | 10.1021/jm00168a040 | D(2) dopamine receptor | 1 |
| 1971309 | 10.1021/jm00168a040 | Dopamine receptors; D1 & D2 | 1 |
Data from ChEMBL 36 via Core Engine