Assay Detail
Binding
CHEMBL675662
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Binding affinity at rat striatal Dopamine receptor D2 using [3H]- piperone radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.42 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288096 | — | — | 1 | 10.28 |
| CHEMBL53294 | — | — | 1 | 9.77 |
| CHEMBL19130 | — | — | 1 | 9.42 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 9.10 |
| CHEMBL53445 | — | — | 1 | 8.95 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.96 |
| CHEMBL276326 | — | — | 1 | 7.75 |
| CHEMBL431946 | — | — | 1 | 7.65 |
| CHEMBL301761 | — | — | 1 | 7.46 |
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 7.23 |
| CHEMBL54183 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288096 | — | Ki | = | 0.053 | nM | 10.28 |
| CHEMBL53294 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL19130 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL53445 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL53 | APOMORPHINE | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL276326 | — | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL431946 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL301761 | — | Ki | = | 34.7 | nM | 7.46 |
| CHEMBL416288 | (S)APOMORPHINE | Ki | = | 58.3 | nM | 7.23 |
| CHEMBL54183 | — | Ki | = | 100.0 | nM | 7.00 |