Assay Detail
Functional
CHEMBL670947
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Agonistic activity against calf striatal Dopamine receptor using [3H]- ADTN radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.94 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288096 | — | — | 1 | 8.94 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 8.82 |
| CHEMBL19130 | — | — | 1 | 8.66 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.43 |
| CHEMBL53294 | — | — | 1 | 8.42 |
| CHEMBL53445 | — | — | 1 | 7.79 |
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 7.32 |
| CHEMBL301761 | — | — | 1 | 6.79 |
| CHEMBL54183 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288096 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL19130 | — | Ki | = | 2.18 | nM | 8.66 |
| CHEMBL53 | APOMORPHINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL53294 | — | Ki | = | 3.84 | nM | 8.42 |
| CHEMBL53445 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL416288 | (S)APOMORPHINE | Ki | = | 47.4 | nM | 7.32 |
| CHEMBL301761 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL54183 | — | Ki | = | 511.0 | nM | 6.29 |