Assay Detail
Binding
CHEMBL666430
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Binding affinity towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]LTD4 radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of a three-dimensional CysLT1 (LTD4) antagonist model with an incorporated amino acid residue from the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL33871 | — | — | 1 | 7.77 |
| CHEMBL284624 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21333 | PRANLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL33871 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL284624 | — | IC50 | = | 17.0 | nM | 7.77 |