Assay Detail
Binding
CHEMBL666432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15177 | MK-571 | — | 1 | 9.10 |
| CHEMBL444331 | — | — | 1 | 7.50 |
| CHEMBL123623 | — | — | 1 | 7.24 |
| CHEMBL339713 | — | — | 1 | 6.60 |
| CHEMBL338876 | — | — | 1 | 5.48 |
| CHEMBL127579 | — | — | 1 | 5.22 |
| CHEMBL127816 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15177 | MK-571 | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL444331 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL123623 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL339713 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL338876 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL127579 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL127816 | — | IC50 | = | 6000.0 | nM | 5.22 |