Assay Detail
Binding
CHEMBL666435
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Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor sites in homogenized guinea pig lung
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | — | 1 | 9.00 |
| CHEMBL21983 | CGP-35949 | — | 1 | 6.00 |
| CHEMBL55714 | — | — | 1 | 5.70 |
| CHEMBL417028 | — | — | 1 | 5.70 |
| CHEMBL267475 | FPL-55712 | — | 1 | 5.40 |
| CHEMBL53333 | — | — | 1 | 5.40 |
| CHEMBL293529 | — | — | 1 | 5.30 |
| CHEMBL54688 | — | — | 1 | 5.30 |
| CHEMBL53512 | — | — | 1 | 5.22 |
| CHEMBL17344 | RITOLUKAST | 2.0 | 1 | 5.22 |
| CHEMBL52877 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL21983 | CGP-35949 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL55714 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL417028 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL53333 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL293529 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL54688 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL53512 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL17344 | RITOLUKAST | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL52877 | — | IC50 | = | 7000.0 | nM | 5.16 |