Compound Detail
CHEMBL21983
CGP-35949 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL21983 |
| Name | CGP-35949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KOMGKDHFTYYZRF-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
487.9
MW (Da)
4.12
ALogP
8
HBA
3
HBD
139.3
PSA (Ų)
0.27
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Kd 1 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cavia porcellus CHEMBL369 | Kd | 7.4 | 7.4 | 39.8 | 1 |
| Cysteinyl leukotriene receptor CHEMBL2094254 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cavia porcellus | Kd | = | 39.81 | nM | 7.4 | Antagonistic activity against LTD4 induced contraction in guinea pig trachea | 1849993 |
| Cysteinyl leukotriene receptor | IC50 | = | 1000.0 | nM | 6.0 | Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor site... | 2547071 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2547071 | 10.1021/jm00128a028 | Cysteinyl leukotriene receptor | 2 |
| 2547071 | 10.1021/jm00128a028 | Cavia porcellus | 2 |
| 1849993 | 10.1021/jm00108a001 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine