Assay Detail
Functional
CHEMBL857041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against LTD4 induced contraction in guinea pig trachea
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Peptide leukotrienes: current status of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.75 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | — | 1 | 10.10 |
| CHEMBL22776 | POBILUKAST | 2.0 | 1 | 8.60 |
| CHEMBL278570 | SULUKAST | 2.0 | 1 | 8.10 |
| CHEMBL21983 | CGP-35949 | — | 1 | 7.40 |
| CHEMBL282253 | L-648051 | — | 1 | 7.30 |
| CHEMBL21247 | L-649923 | — | 1 | 7.20 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.70 |
| CHEMBL22016 | ABLUKAST | 2.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL22776 | POBILUKAST | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL278570 | SULUKAST | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL21983 | CGP-35949 | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL282253 | L-648051 | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL21247 | L-649923 | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL267475 | FPL-55712 | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL22016 | ABLUKAST | Kd | = | 251.19 | nM | 6.60 |