Compound Detail
CHEMBL278570
SULUKAST 🧪 Phase II
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🧪 Phase II
CCCCCCCCC/C=C\C=C\[C@@H](SCCC(=O)O)[C@@H](O)c1cccc(-c2nnn[nH]2)c1
Basic Information
| ChEMBL ID | CHEMBL278570 |
| Name | SULUKAST |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YPHOSUPSOWQQCB-AFOLHBCXSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names
Molecular Properties
472.7
MW (Da)
5.73
ALogP
6
HBA
3
HBD
112.0
PSA (Ų)
0.20
QED
1
Ro5 Violations
17
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Kd 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cavia porcellus CHEMBL369 | Kd | 8.3 | 8.2 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cavia porcellus | Kd | = | 5.012 | nM | 8.3 | Compound was tested for LTD4 induced guinea pig trachea contraction | 8709092 |
| Cavia porcellus | Kd | = | 7.943 | nM | 8.1 | Antagonistic activity against LTD4 induced contraction in guinea pig trachea | 1849993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8709092 | 10.1021/jm960088k | Cavia porcellus | 1 |
| 8709092 | 10.1021/jm960088k | Cysteinyl leukotriene receptor 1 | 1 |
| 1849993 | 10.1021/jm00108a001 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine