Assay Detail
Functional
CHEMBL691149
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Compound was tested for LTD4 induced guinea pig trachea contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Modulators of leukotriene biosynthesis and receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.05 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.30 |
| CHEMBL22776 | POBILUKAST | 2.0 | 1 | 8.60 |
| CHEMBL278570 | SULUKAST | 2.0 | 1 | 8.30 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL787 | MONTELUKAST | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL22776 | POBILUKAST | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL278570 | SULUKAST | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL267475 | FPL-55712 | Kd | = | 1000.0 | nM | 6.00 |