Assay Detail
Binding
CHEMBL666489
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Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung parenchyma |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.57 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50422 | — | — | 1 | 7.39 |
| CHEMBL422404 | — | — | 1 | 7.24 |
| CHEMBL301928 | — | — | 1 | 7.10 |
| CHEMBL298727 | — | — | 1 | 6.80 |
| CHEMBL50733 | — | — | 1 | 6.63 |
| CHEMBL298939 | — | — | 1 | 5.95 |
| CHEMBL52906 | — | — | 1 | 5.74 |
| CHEMBL298642 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50422 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL422404 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL301928 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL298727 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL50733 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL298939 | — | Ki | = | 1119.0 | nM | 5.95 |
| CHEMBL52906 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL298642 | — | Ki | = | 1900.0 | nM | 5.72 |