Assay Detail
Binding
CHEMBL666615
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Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.53 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318401 | — | — | 1 | 6.56 |
| CHEMBL97483 | — | — | 1 | 5.84 |
| CHEMBL98408 | — | — | 1 | 5.09 |
| CHEMBL503274 | — | — | 1 | 4.61 |
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318401 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL97483 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL98408 | — | Ki | = | 8170.0 | nM | 5.09 |
| CHEMBL503274 | — | Ki | = | 24700.0 | nM | 4.61 |
| CHEMBL67279 | TALABOSTAT | Ki | = | 125000.0 | nM | - |