Assay Detail
Binding
CHEMBL666764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.06 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300019 | — | — | 1 | 9.52 |
| CHEMBL89752 | — | — | 1 | 7.37 |
| CHEMBL554565 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300019 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL89752 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL554565 | — | Ki | = | 51.0 | nM | 7.29 |