Assay Detail
Binding
CHEMBL667485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Dopamine receptor D2 from rat brain corpus striatum membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.29 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106622 | — | — | 1 | 10.15 |
| CHEMBL288096 | — | — | 1 | 9.49 |
| CHEMBL322574 | — | — | 1 | 9.05 |
| CHEMBL53294 | — | — | 1 | 8.99 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 8.32 |
| CHEMBL107041 | — | — | 1 | 8.26 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.18 |
| CHEMBL106886 | — | — | 1 | 7.01 |
| CHEMBL107519 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106622 | — | IC50 | = | 0.071 | nM | 10.15 |
| CHEMBL288096 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL322574 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL53294 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL107041 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 66.7 | nM | 7.18 |
| CHEMBL106886 | — | IC50 | = | 97.6 | nM | 7.01 |
| CHEMBL107519 | — | IC50 | = | 704.0 | nM | 6.15 |