Assay Detail

CHEMBL667486

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Binding

Binding affinity against Dopamine receptor D2 receptor of rat corpus striatal tissue with [3H]spiperone

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL339) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL339) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL339

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Expert

Target

D(2) dopamine receptor (CHEMBL339) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.

Cipollina JA, Ruediger EH, New JS, Wire ME, Shepherd TA, Smith DW, Yevich JP.
J Med Chem (1991) 34 : 3316 -3328
PubMed 1683407 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.08	8.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL35057	TIOSPIRONE	2.0	1	8.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL35057	TIOSPIRONE	IC50	=	8.4	nM	8.08