Assay Detail
Binding
CHEMBL667488
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Binding affinity to dopamine receptor D2 using a [3H]-spiperone binding assay in rat cortical membranes
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.36 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 9.32 |
| CHEMBL125291 | — | — | 1 | 8.64 |
| CHEMBL123584 | — | — | 1 | 8.62 |
| CHEMBL125483 | — | — | 1 | 8.54 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.39 |
| CHEMBL421244 | — | — | 1 | 8.24 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.92 |
| CHEMBL421239 | — | — | 1 | 7.75 |
| CHEMBL301956 | — | — | 1 | 7.72 |
| CHEMBL341229 | — | — | 1 | 7.72 |
| CHEMBL332385 | — | — | 1 | 7.70 |
| CHEMBL122018 | — | — | 1 | 7.66 |
| CHEMBL332077 | — | — | 1 | 7.62 |
| CHEMBL122113 | — | — | 1 | 7.60 |
| CHEMBL332913 | — | — | 1 | 7.57 |
| CHEMBL332365 | — | — | 1 | 7.42 |
| CHEMBL123094 | — | — | 1 | 7.38 |
| CHEMBL339919 | — | — | 1 | 7.20 |
| CHEMBL122047 | — | — | 1 | 6.92 |
| CHEMBL331545 | — | — | 1 | 6.89 |
| CHEMBL123027 | — | — | 1 | 6.85 |
| CHEMBL122042 | — | — | 1 | 6.72 |
| CHEMBL338022 | — | — | 1 | 6.72 |
| CHEMBL331193 | — | — | 1 | 6.72 |
| CHEMBL333774 | — | — | 1 | 6.70 |
| CHEMBL332425 | — | — | 1 | 6.40 |
| CHEMBL122269 | — | — | 1 | 6.23 |
| CHEMBL123640 | — | — | 1 | 6.19 |
| CHEMBL125072 | — | — | 1 | 6.10 |
| CHEMBL122384 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL125291 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL123584 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL125483 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL12713 | SERTINDOLE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL421244 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL421239 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL301956 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL341229 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL332385 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL122018 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL332077 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL122113 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL332913 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL332365 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL123094 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL339919 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL122047 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL331545 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL123027 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL122042 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL338022 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL331193 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL333774 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL332425 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL122269 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL123640 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL125072 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL122384 | — | IC50 | = | 4800.0 | nM | 5.32 |