Assay Detail
Binding
CHEMBL667492
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Binding affinity against dopamine receptor D2 in rat corpus striatal tissue using [3H]spiperone as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.99 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115486 | — | — | 1 | 7.41 |
| CHEMBL114451 | — | — | 1 | 7.28 |
| CHEMBL115367 | — | — | 1 | 7.17 |
| CHEMBL326775 | — | — | 1 | 6.96 |
| CHEMBL321591 | — | — | 1 | 6.82 |
| CHEMBL114131 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115486 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL114451 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL115367 | — | IC50 | = | 68.3 | nM | 7.17 |
| CHEMBL326775 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL321591 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL114131 | — | IC50 | = | 491.0 | nM | 6.31 |