Assay Detail
Binding
CHEMBL667496
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Binding affinity for Dopamine receptor D2 was assessed in vitro in rat striatal membranes using [3H]-SCH- 23390 radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.17 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.97 |
| CHEMBL418791 | — | — | 1 | 6.92 |
| CHEMBL321040 | — | — | 1 | 6.68 |
| CHEMBL111348 | — | — | 1 | 6.45 |
| CHEMBL113053 | — | — | 1 | 6.27 |
| CHEMBL113477 | — | — | 1 | 6.20 |
| CHEMBL320481 | — | — | 1 | 5.70 |
| CHEMBL68680 | — | — | 1 | 5.52 |
| CHEMBL326781 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL418791 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL321040 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL111348 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL113053 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL113477 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL320481 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL68680 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL326781 | — | IC50 | = | 15500.0 | nM | 4.81 |