Assay Detail
Binding
CHEMBL667498
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Binding affinity towards rat Dopamine receptor D2 was evaluated using [3H]- spiroperidol as radioligand
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.01 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.28 |
| CHEMBL26929 | — | — | 1 | 7.75 |
| CHEMBL172601 | — | — | 1 | 7.55 |
| CHEMBL145432 | — | — | 1 | 7.21 |
| CHEMBL147678 | — | — | 1 | 7.04 |
| CHEMBL144445 | — | — | 1 | 7.00 |
| CHEMBL147440 | — | — | 1 | 7.00 |
| CHEMBL322275 | — | — | 1 | 6.96 |
| CHEMBL341893 | — | — | 1 | 6.96 |
| CHEMBL143728 | — | — | 1 | 6.92 |
| CHEMBL343432 | — | — | 1 | 6.89 |
| CHEMBL342518 | — | — | 1 | 6.87 |
| CHEMBL444590 | — | — | 1 | 6.85 |
| CHEMBL143110 | — | — | 1 | 6.80 |
| CHEMBL357176 | — | — | 1 | 6.77 |
| CHEMBL144417 | — | — | 1 | 6.68 |
| CHEMBL147387 | — | — | 1 | 6.56 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.55 |
| CHEMBL148055 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL26929 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL172601 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL145432 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL147678 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL144445 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147440 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL322275 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL341893 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL143728 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL343432 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL342518 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL444590 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL143110 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL357176 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL144417 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL147387 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL148055 | — | IC50 | = | 303.0 | nM | 6.52 |