Assay Detail
Binding
CHEMBL667499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.17 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28209 | — | — | 1 | 7.81 |
| CHEMBL326017 | — | — | 1 | 7.14 |
| CHEMBL110968 | — | — | 1 | 6.94 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.55 |
| CHEMBL321184 | — | — | 1 | 6.48 |
| CHEMBL26426 | — | — | 1 | 6.35 |
| CHEMBL108942 | — | — | 1 | 6.23 |
| CHEMBL28063 | — | — | 1 | 6.12 |
| CHEMBL111760 | — | — | 1 | 6.11 |
| CHEMBL324637 | — | — | 1 | 6.09 |
| CHEMBL325565 | — | — | 1 | 6.05 |
| CHEMBL107486 | — | — | 1 | 5.97 |
| CHEMBL107921 | — | — | 1 | 5.96 |
| CHEMBL325092 | — | — | 1 | 5.92 |
| CHEMBL108245 | — | — | 1 | 5.73 |
| CHEMBL323242 | — | — | 1 | 5.72 |
| CHEMBL325079 | — | — | 1 | 5.67 |
| CHEMBL107503 | — | — | 1 | 5.61 |
| CHEMBL108858 | — | — | 1 | 5.53 |
| CHEMBL320587 | — | — | 1 | 5.39 |
| CHEMBL109263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28209 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL326017 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL110968 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL321184 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL26426 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL108942 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL28063 | — | IC50 | = | 761.0 | nM | 6.12 |
| CHEMBL111760 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL324637 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL325565 | — | IC50 | = | 882.0 | nM | 6.05 |
| CHEMBL107486 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL107921 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL325092 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL108245 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL323242 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL325079 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL107503 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL108858 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL320587 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL109263 | — | IC50 | > | 10000.0 | nM | - |