Assay Detail
Functional
CHEMBL667652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity against prostate carcinoma (DU-145) cells assayed by inhibition of [3H]-labeled thymidine incorporation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.46 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.95 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.31 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.45 |
| CHEMBL138287 | — | — | 1 | 4.76 |
| CHEMBL138636 | — | — | 1 | 4.70 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.60 |
| CHEMBL139865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.89 | nM | 8.31 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL138287 | — | IC50 | = | 17163.0 | nM | 4.76 |
| CHEMBL138636 | — | IC50 | = | 19855.0 | nM | 4.70 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 24920.0 | nM | 4.60 |
| CHEMBL139865 | — | IC50 | = | 132980.0 | nM | - |