Assay Detail
Binding
CHEMBL668243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against dopamine receptor D1
18
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.25 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.37 |
| CHEMBL293158 | — | — | 2 | 8.18 |
| CHEMBL137420 | — | — | 1 | 8.08 |
| CHEMBL334350 | — | — | 1 | 8.08 |
| CHEMBL303993 | — | — | 2 | 8.04 |
| CHEMBL299056 | — | — | 2 | 7.06 |
| CHEMBL446396 | — | — | 1 | 6.85 |
| CHEMBL336218 | — | — | 1 | 6.85 |
| CHEMBL300778 | — | — | 1 | 6.75 |
| CHEMBL135318 | — | — | 1 | 6.73 |
| CHEMBL57988 | — | — | 1 | 6.55 |
| CHEMBL323771 | — | — | 1 | 6.38 |
| CHEMBL445129 | — | — | 1 | 5.86 |
| CHEMBL434809 | — | — | 1 | - |
| CHEMBL109723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL293158 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL137420 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL334350 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL303993 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL303993 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL299056 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL446396 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL336218 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL299056 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL300778 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL135318 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL57988 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL323771 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL293158 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL445129 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL434809 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL109723 | — | Ki | < | 10000.0 | nM | - |