Assay Detail
Binding
CHEMBL668636
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Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.11 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 8.72 |
| CHEMBL71600 | — | — | 1 | 8.22 |
| CHEMBL58422 | — | — | 1 | 6.29 |
| CHEMBL56666 | — | — | 1 | 6.28 |
| CHEMBL294012 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL71600 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL58422 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL56666 | — | Ki | = | 531.0 | nM | 6.28 |
| CHEMBL294012 | — | Ki | = | 898.0 | nM | 6.05 |