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Compound Detail

CHEMBL56666

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CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21

Basic Information

ChEMBL ID CHEMBL56666
Phase Preclinical
Structure Type MOL
InChI Key DMJWENQHWZZWDF-HKUYNNGSSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

313.8
MW (Da)
3.98
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C19H20ClNO
MW 313.83
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.52

Activity Summary

Ki 5 meas. best 6.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1A) dopamine receptor
CHEMBL265
Ki 6.33 6.31 473.6 2
D(1A) dopamine receptor
CHEMBL2056
Ki 6.28 6.28 531.0 1
D(2) dopamine receptor
CHEMBL339
Ki 5.46 5.25 3476.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2666667 10.1021/jm00128a038 D(1A) dopamine receptor 2
2666667 10.1021/jm00128a038 D(2) dopamine receptor 2
1973733 10.1021/jm00170a025 D(1A) dopamine receptor 1

Data from ChEMBL 36 via Core Engine