Assay Detail
Binding
CHEMBL673578
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Displacement of [3H]spiperone from rat striatal homogenate dopamine receptor D2
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.42 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 6.29 |
| CHEMBL58205 | — | — | 1 | 5.82 |
| CHEMBL292451 | — | — | 1 | 5.61 |
| CHEMBL58422 | — | — | 1 | 5.52 |
| CHEMBL56666 | — | — | 2 | 5.46 |
| CHEMBL59139 | — | — | 1 | 5.39 |
| CHEMBL294215 | — | — | 1 | 5.19 |
| CHEMBL294221 | — | — | 1 | 5.10 |
| CHEMBL294012 | — | — | 1 | 4.79 |
| CHEMBL442740 | — | — | 1 | - |
| CHEMBL294186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL58205 | — | Ki | = | 1505.0 | nM | 5.82 |
| CHEMBL292451 | — | Ki | = | 2477.0 | nM | 5.61 |
| CHEMBL58422 | — | Ki | = | 3046.0 | nM | 5.52 |
| CHEMBL56666 | — | Ki | = | 3476.0 | nM | 5.46 |
| CHEMBL59139 | — | Ki | = | 4115.0 | nM | 5.39 |
| CHEMBL294215 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL294221 | — | Ki | = | 7873.0 | nM | 5.10 |
| CHEMBL56666 | — | Ki | = | 9073.0 | nM | 5.04 |
| CHEMBL294012 | — | Ki | = | 16317.0 | nM | 4.79 |
| CHEMBL442740 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL294186 | — | Ki | > | 100000.0 | nM | - |