Assay Detail
Binding
CHEMBL670441
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Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.74 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 8.72 |
| CHEMBL59139 | — | — | 1 | 8.48 |
| CHEMBL58205 | — | — | 1 | 8.15 |
| CHEMBL292451 | — | — | 1 | 7.63 |
| CHEMBL294221 | — | — | 1 | 7.14 |
| CHEMBL56666 | — | — | 2 | 6.33 |
| CHEMBL58422 | — | — | 1 | 6.28 |
| CHEMBL294012 | — | — | 1 | 6.05 |
| CHEMBL294215 | — | — | 1 | 5.78 |
| CHEMBL294186 | — | — | 1 | 5.38 |
| CHEMBL442740 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL59139 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL58205 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL292451 | — | Ki | = | 23.6 | nM | 7.63 |
| CHEMBL294221 | — | Ki | = | 72.6 | nM | 7.14 |
| CHEMBL56666 | — | Ki | = | 473.6 | nM | 6.33 |
| CHEMBL56666 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL58422 | — | Ki | = | 531.0 | nM | 6.28 |
| CHEMBL294012 | — | Ki | = | 898.0 | nM | 6.05 |
| CHEMBL294215 | — | Ki | = | 1664.0 | nM | 5.78 |
| CHEMBL294186 | — | Ki | = | 4197.0 | nM | 5.38 |
| CHEMBL442740 | — | Ki | = | 24397.0 | nM | 4.61 |