Assay Detail
Binding
CHEMBL669055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.70 |
| CHEMBL35057 | TIOSPIRONE | 2.0 | 1 | 7.66 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.52 |
| CHEMBL276175 | — | — | 1 | 6.85 |
| CHEMBL269176 | — | — | 1 | 6.77 |
| CHEMBL274334 | — | — | 1 | 6.57 |
| CHEMBL10880 | — | — | 1 | 6.17 |
| CHEMBL269458 | — | — | 1 | 6.14 |
| CHEMBL276378 | — | — | 1 | 6.13 |
| CHEMBL10366 | — | — | 1 | 6.03 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.00 |
| CHEMBL10640 | — | — | 1 | 6.00 |
| CHEMBL274306 | — | — | 1 | 5.70 |
| CHEMBL418526 | — | — | 1 | 5.70 |
| CHEMBL268267 | — | — | 1 | 5.57 |
| CHEMBL10821 | — | — | 1 | 5.55 |
| CHEMBL10355 | — | — | 1 | 5.54 |
| CHEMBL10875 | — | — | 1 | 5.43 |
| CHEMBL10963 | — | — | 1 | 5.39 |
| CHEMBL430329 | — | — | 1 | - |
| CHEMBL10658 | — | — | 1 | - |
| CHEMBL418340 | — | — | 1 | - |
| CHEMBL10692 | — | — | 1 | - |
| CHEMBL10194 | — | — | 1 | - |
| CHEMBL10623 | — | — | 1 | - |
| CHEMBL10546 | — | — | 1 | - |
| CHEMBL273505 | — | — | 1 | - |
| CHEMBL274566 | — | — | 1 | - |
| CHEMBL264472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL35057 | TIOSPIRONE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL276175 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL269176 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL274334 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL10880 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL269458 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL276378 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL10366 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL10640 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL274306 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL418526 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL268267 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL10821 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL10355 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL10875 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL10963 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL430329 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10658 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL418340 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10692 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10194 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10623 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10546 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL273505 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274566 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL264472 | — | IC50 | > | 20000.0 | nM | - |