Assay Detail
Binding
CHEMBL669059
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Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]domperidone as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.85 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.26 |
| CHEMBL325238 | — | — | 1 | 6.78 |
| CHEMBL112124 | — | — | 1 | 6.47 |
| CHEMBL115508 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL325238 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL112124 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL115508 | — | IC50 | = | 1250.0 | nM | 5.90 |