Assay Detail
Binding
CHEMBL669953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against dopamine D2 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.66 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.06 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.70 |
| CHEMBL304902 | CLOTHIAPINE | 2.0 | 1 | 8.35 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.90 |
| CHEMBL67284 | ISOCLOTHIAPINE | — | 1 | 7.52 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.34 |
| CHEMBL63756 | FLUPERLAPINE | 2.0 | 1 | 6.88 |
| CHEMBL433744 | — | — | 1 | 6.58 |
| CHEMBL149240 | — | — | 1 | 6.44 |
| CHEMBL147463 | — | — | 1 | 5.92 |
| CHEMBL151809 | — | — | 1 | 5.91 |
| CHEMBL151263 | — | — | 1 | 5.64 |
| CHEMBL356076 | — | — | 1 | 5.39 |
| CHEMBL435441 | — | — | 1 | 5.18 |
| CHEMBL149108 | — | — | 1 | 4.96 |
| CHEMBL146741 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.871 | nM | 9.06 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL304902 | CLOTHIAPINE | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL67284 | ISOCLOTHIAPINE | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL42 | CLOZAPINE | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL63756 | FLUPERLAPINE | Ki | = | 131.83 | nM | 6.88 |
| CHEMBL433744 | — | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL149240 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL147463 | — | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL151809 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL151263 | — | Ki | = | 2290.87 | nM | 5.64 |
| CHEMBL356076 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL435441 | — | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL149108 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL146741 | — | Ki | = | 14791.08 | nM | 4.83 |